The Duke of Kent research fellows are working tirelessly to make advances in burn and scar treatments. Listed here are some of the most recent and notable publications in the form of both papers in peer reviewed journals, as well as books and book chapters.

 

Papers Published

Wright, EH, Furniss, D, Harris, A, Pleat, JM, Tyler, MPH.  A human model of burn injury that quantifies the benefit of cooling as a first aid measure.  British Journal of SurgeryIn press, 2019

M Song, A Armstrong, A Murray. Acid Attacks: Broadening the multidisciplinary team to improve outcomes. Burns, Jun 20, 2019.

Major M, Freund MK, Burch KS, Mancuso N, Ng M, Furniss D, Pasaniuc B, Ophoff RA. Integrative analysis of Dupuytren’s disease identifies novel risk locus and reveals a shared genetic etiology with BMI.    Genet Epidemiol. 2019 May 13. doi: 10.1002/gepi.22209. [Epub ahead of print]

Wright S, Issa F. Hypoimmunogenic genetically-modified induced pluripotent stem cells for tissue regeneration. Transplantation. 2019 Apr 8. doi: 10.1097/TP.0000000000002754

Issa F, Milward K, Goto R, Betts G, Wood KJ, Hester J. Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo.  Front Immunol. 2019 Apr 24;10:889. doi: 10.3389/fimmu.2019.00889. eCollection 2019.

Phillips GSA, Gore S, Ramsden A, Furniss D. Lymphaticovenular anastomosis in the treatment of secondary lymphoedema of the legs after cancer treatment.  J Plast Reconstr Aesthet Surg. 2019 Mar 23. pii: S1748-6815(19)30122-6. doi: 10.1016/j.bjps.2019.03.013. [Epub ahead of print]

Jones ME, Davies MAM, Shah K, Kemp S, Peirce N, Leyland KM, Stokes KA, Judge AD, Newton JL, Furniss D, Arden NK.  J Sci Med Sport. The prevalence of hand and wrist osteoarthritis in elite former cricket and rugby union players.  2019 Mar 16. pii: S1440-2440(18)30971-X. doi: 10.1016/j.jsams.2019.03.004. [Epub ahead of print]

Wiberg A, Ng M, Schmid AB, Smillie RW, Baskozos G, Holmes MV, Künnapuu K, Mägi R, Bennett DL, Furniss D.  A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nat Commun. 2019 Mar 4;10(1):1030. doi: 10.1038/s41467-019-08993-6.

Craig RS, Lane JCE, Carr AJ, Furniss D, Collins GS, Rees JL. Serious adverse events and lifetime risk of reoperation after elective shoulder replacement: population based cohort study using hospital episode statistics for England.    BMJ. 2019 Feb 20;364:l298. doi: 10.1136/bmj.l298.

Markkula SP, Leung N, Allen VB, Furniss D.  Surgical interventions for the prevention or treatment of lymphoedema after breast cancer treatment.  Cochrane Database Syst Rev. 2019 Feb 19;2:CD011433. doi: 10.1002/14651858.CD011433.pub2.

Manley OWG, Wormald JCR, Furniss D. The changing shape of hand trauma: an analysis of Hospital Episode Statistics in England.  J Hand Surg Eur Vol. 2019 Jun;44(5):532-536. doi: 10.1177/1753193419828986. Epub 2019 Feb 14.

Riesmeijer SA, Manley OWG, Ng M, Nolte IM, Broekstra DC, Werker PMN, Furniss D. A Weighted Genetic Risk Score Predicts Surgical Recurrence Independent of High-Risk Clinical Features in Dupuytren’s Disease.  Plast Reconstr Surg. 2019 Feb;143(2):512-518. doi: 10.1097/PRS.0000000000005208

McCallion O, Hester J, Issa F.  Deciphering the Contribution of γδ T Cells to Outcomes in Transplantation.  Transplantation. 2018 Dec;102(12):1983-1993. doi: 10.1097/TP.0000000000002335.

Ali SR, Pleat J.  The Gallipot Method-A Point of Technique for Safe and Easy Staple Removal From Split-Thickness Skin Grafts. Eplasty. 2018 Nov 19;18:e32. eCollection 2018

Shah K, Furniss D, Cogswell L.  Letter about a Published Paper: The hand injury caused by cutting avocado in 18 patients.  J Hand Surg Eur Vol. 2018 Oct;43(8):895-896. doi: 10.1177/1753193418789305.

Edmondson SJ, Murray A. Is the time right to put down the knife? A letter in response with a call for change in primary research outcomes to tackle the global burden of long-term scarring. Burns. 2018 Nov;44(7):1860-1861. doi: 10.1016/j.burns.2018.05.003. Epub 2018 Aug 1.

Edmondson SJ, Ali Jumabhoy I, Murray A.  Time to start putting down the knife: A systematic review of burns excision tools of randomised and non-randomised trials.  Burns. 2018 Nov;44(7):1721-1737. doi: 10.1016/j.burns.2018.01.012. Epub 2018 Feb 16. Review.

C Brady, S J Edmondson, A Murray. Ensuring sustainability for UK Burns Services: workforce planning for burns consultants., Annals of Plastic Surgery, Sept 2018.

Kawai K, Uchiyama M, Hester J, Wood K, Issa F. Regulatory T cells for tolerance.  Hum Immunol. 2018 May;79(5):294-303. doi: 10.1016/j.humimm.2017.12.013. Epub 2017 Dec 27. Review.

D Markeson, A Arnout, M Tyler, A Murray. An epidemiological study of first aid techniques for paediatric burns in different groups and an analysis of outcomes. ABA, Journal of Burn Care and Research, April 2018.

Liu J, Ren J, Su L, Cheng S, Zhou J, Ye X, Dong Y, Sun S, Qi F, Liu Z, Pleat J, Zhai H, Zhu N.  Human adipose tissue-derived stem cells inhibit the activity of keloid fibroblasts and fibrosis in a keloid model by paracrine signaling.  Burns. 2018 Mar;44(2):370-385. doi: 10.1016/j.burns.2017.08.017. Epub 2017 Oct 10.

Adigbli G, Issa F.  Preserving Treg Function: Beyond mTOR Inhibitors.  Transplantation. 2018 Feb;102(2):179-182. doi: 10.1097/TP.0000000000002042.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.  Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.

Watt SM, Pleat JM.  Stem cells, niches and scaffolds: Applications to burns and wound care.  Adv Drug Deliv Rev. 2018 Jan 1;123:82-106. doi: 10.1016/j.addr.2017.10.012. Epub 2017 Oct 26. Review.

Chapman LA, Shipley RJ, Whiteley JP, Ellis MJ, Byrne HM, Waters SL. Optimising cell aggregate expansion in a perfused hollow fibre bioreactor via mathematical modelling.  PLoS One 2014; 26: 9(8)

Issa F and Wood KJ. The potential role for regulatory T cell therapy in vascularised composite allograft transplantation. Curr Opin Organ Transplant 2014;19(6):558-65.

Wung N, Acott SM, Tosh D, Ellis MJ. Hollow fibre membrane bioreactors for tissue engineering applications. Biotechnol Lett 2014; 36(12):  2357-66

Fitzgerald O’Connor E, Frew Q, Din A, Pleat J, Ashraff S, Ghazi-Nouri S, El-Muttardi N, Philp B,   Dziewulski P. Periorbital burns – A 6 year review of management and outcome. Burns 2014; S0305-4179(14)00296-4. doi: 10.1016/j.burns.2014.08.022.

Griffiths C, Armstrong-James L, White P, Rumsey N, Pleat J, Harcourt D. A systematic review of patient reported outcome measures (PROMs) used in child and adolescent burn research. Burns 2014; S0305- 4179(14)00246-0

Landwehr-Kenzel S, Issa F, Luu SH, Schmück M, Lei H, Zobel A, Thiel A, Babel N, Wood KJ, Volk HD, Reinke P. Novel GMP-compliant protocol employing an allogeneic B cell bank to induce clonal expansion of even low-abundance alloantigen-specific natural regulatory T cells. Am J Transplant 2014; 14(3):594-606

Newey SE, Tsaknakis G, Khoo CP, Athanassopoulos T, Camicia R, Zhang Y, Grabowska R, HarrisAL, Roubelakis MG, Watt SM. The hematopoietic chemokine CXCL12 promotes integration of human endothelial colony forming cell-derived cells into immature vessel networks. Stem Cells Dev 2014;23(22):2730-43

Paget JT, Burge TS. Keeping New Delhi metallo-β-lactamase-1 at the door. J Burn Care Res 2014; 35(2):e125-7

Allin B, Ceresa C, Issa F,  Casey G, Espinosa O, Reddy S, Sinha S, Giele H, Friend P,  Vaidya   A. A single centre experience of abdominal wall graft rejection after combined intestinal and abdominal wall transplantation.  Am J Transplant 2013; 13(8):2211-5

Bendon CL, Furniss D, McNab I. Response to “Scaphoid waist nonunion with humpback deformity treated without structural bone graft”. J Hand Surg Am 2013;   38(9):1866-7

Chandrasekharan D, Issa F, Wood KJ. Achieving operational tolerance in transplantation: how can lessons from the clinic inform research directions? Transplant Int 2013; 26(6):576-89

Capstick R, Bragg T,  Giele H, Furniss D. Sibling recurrence risk in Dupuytren’s disease. J Hand Surg 2013;38(4):424-9

Evgeniou E, Markeson D, Iyer S, Armstrong A. The management of animal bites in the United kingdom. Eplasty 2013;13:e27

Finnerty CC, Mabvuure NT, Ali A, Kozar RA, Herndon DN. The surgically induced stress response. J Parenter Enteral Nutr 2013; 37(5): 21-9.

Goto R, Issa F, Heidt S, Taggart D, Wood KJ. Ischaemia-reperfusion injury accelerates human antibody mediated transplant vasculopathy. Transplantation 2013; 96(2):139-45

Isherwood J, Furniss D, Ramsden A. The effectiveness of an educational intervention in improving accuracy of drain output measurements. Int J Surg 2013;11(8):688

Issa F, Robb R, Wood KJ. The where and when of T cell regulation in transplantation.  Trends Immunol 2013; 34(3): 107-113

Markeson D, Pleat JM, Sharpe JR, Harris AL, Seifalian AM, Watt SM. Scarring, stem cells, scaffolds and skin repair. J Tissue Eng Regen Med 2013; doi:  10.1002/term.1841

Markeson DB, Evgeniou E, Choa R, Iyer S. The simple transverse intraosseous phalangeal suture for zone 1 flexor digitorum profundus injuries: case series and review of the literature. Plast Reconstr Surg 2013;131(5):788e-93e

Milward J, Issa F, Hester J, Lombardi G, Madrigal A, Wood KJ. Multiple unit pooled umbilical cord blood Treg are a viable source of therapeutic regulatory T cells. Transplantation 2013; 95(1): 85-93.

Murphy G, Markeson D, Choa R, Armstrong A. Raised serum lactate: a marker of necrotizing fasciitis? J Plast Reconstr Aesthet Surg 2013;  66(12):1712-6

Roubelakis MG, Tsaknakis G, Pappa KI, Anagnou NP, Watt SM (2013). Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization. PLoS One 2013;8(1):e54747.

Watt SM, Gullo F, van der Garde M, Markeson D, Camicia R, Khoo CP, Zwaginga JJ. The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential. Br Med Bull 2013;108:25-53

 

Books or Book Chapters  Published

Issa, F. Transplant Tolerance: Lessons from Experimental Models. NDT Educational

Mabvuure NT, Munson C, Pleat J. The pathophysiological response to burns. In: The Oxford Handbook of Burns.  OUP,  Oxford 2014.

Watt SM, Leeson P, Cai S, Markeson D, Khoo CP, Newton L, Zhang Y, Sourri S, Channon KM. Cord and cord blood endothelial cells- Chapter 5. In: Cord Blood Stem Cells and Regenerative Medicine. C Stavropoulos et al.eds. Elsevier Press, Amsterdam, The Netherlands 2014.

 

Oral Presentions

Patricia Perez-Esteban, “Scaling-up of Keratinocyte Expansion for the Treatment of Large Burn Wounds”, lifETIME CDT meeting, Birmingham, 2019

Rebecca Arroyo Hornero, “CD70 expression renders human regulatory T cells dysfunctional”, Oxford Immunology Symposium, 2018

Riyam Mistry, “A human trial of an anti-scarring therapy”.  Vocational Training Charitable Trust, London, 2018

Alexandra Murray, “Acid Attacks in the UK, Oral presentation”, British Burns Association Congress, Swansea 2018

Alexandra Murray, “Paediatric Scalds – management and outcomes”, Oral presentation, British Burns Association Congress, Swansea 2018

Guy Stanley, “An international study of public perceptions of keloids”, Australian and New Zealand Burns Association, 2018

 

Poster Presentations

BEST Protocol, British Burns Association Congress, Leeds 2019

Paediatric Scald scar follow up, British Burns Association Congress, Leeds 2019.  Best in category.

 

Higher Degrees

Hugh Wright, University of Oxford, Doctorate of Philosophy, 2019.

Rebeca Arroyo Hornero, University of Oxford, DPhil Surgical Sciences, 2019

Riyam Mistry transfer viva; Master of Surgery, 2019