The Duke of Kent research fellows are working tirelessly to make advances in burn and scar treatments. Listed here are some of the most recent and notable publications in the form of both papers in peer reviewed journals, as well as books and book chapters.
Papers Published
Cross A, Issa F. Unraveling Renal Transplant Rejection: How Can We Measure Intragraft Cell-Cell Interactions? Transplantation. 2024 Jul 24. doi: 10.1097/TP.0000000000005136. Epub ahead of print. PMID: 39044324.
Brook MO, Hennessy C, Hester J, Hammad S, Alzhrani A, Rombach I, Dutton S, Lombardi G, Wood KJ, Friend P, Harden PN, Issa F. Late Treatment With Autologous Expanded Regulatory T-cell Therapy After Alemtuzumab Induction Is Safe and Facilitates Immunosuppression Minimization in Living Donor Renal Transplantation. Transplantation. 2024 Jun 7. doi: 10.1097/TP.0000000000005065. Epub ahead of print. PMID: 38845088.
Cendales LC, Farris AB, Rosales I, Elder D, Gamboa-Dominguez A, Gelb B, Issa F, Ravindra K, Nankivell BJ, Talbot S, Xu XG, Moris D, Drachenberg CB, Kanitakis J, Selim MA. Banff 2022 Vascularized Composite Allotransplantation Meeting Report: Diagnostic criteria for vascular changes. Am J Transplant. 2024 May;24(5):716-723. doi: 10.1016/j.ajt.2023.12.023. Epub 2024 Jan 28. PMID: 38286355.
Adigbli G, Woolley L, Issa F. Complex Lymphatic Drainage in Head and Neck Cutaneous Melanoma and SLNB Outcomes. JAMA Otolaryngol Head Neck Surg. 2023 Sep 1;149(9):853-854. doi: 10.1001/jamaoto.2023.1584. PMID: 37410456.
Escoto M, Issa F, Cayouette F, Consolo H, Chaudhury P, Dhanani S, Jiang W, Oniscu GC, Murphy N, Rockell K, Weiss MJ, Dieudé M. Research and Innovation in Organ Donation: Recommendations From an International Consensus Forum. Transplant Direct. 2023 Apr 28;9(5):e1446. doi: 10.1097/TXD.0000000000001446. PMID: 37138559; PMCID: PMC10150888.
Short S, Lewik G, Issa F. An Immune Atlas of T Cells in Transplant Rejection: Pathways and Therapeutic Opportunities. Transplantation. 2023 Nov 1;107(11):2341-2352. doi: 10.1097/TP.0000000000004572. Epub 2023 Oct 21. PMID: 37026708; PMCID: PMC10593150.
Cross AR, Gartner L, Hester J, Issa F. Opportunities for High-plex Spatial Transcriptomics in Solid Organ Transplantation. Transplantation. 2023 Dec 1;107(12):2464-2472. doi: 10.1097/TP.0000000000004587. Epub 2023 Mar 22. PMID: 36944604.
Hennessy C, Deptula M, Hester J, Issa F. Barriers to Treg therapy in Europe: From production to regulation. Front Med (Lausanne). 2023 Jan 19;10:1090721. doi: 10.3389/fmed.2023.1090721. PMID: 36744143; PMCID: PMC9892909.
O’Neil A, Brook M, Abdul-Wahab S, Hester J, Lombardi G, Issa F. A GMP Protocol for the Manufacture of Tregs for Clinical Application. Methods Mol Biol. 2023;2559:205-227. doi: 10.1007/978-1-0716-2647-4_14. PMID: 36180635.
Mistry R, Issa F. No statistically significant difference in long term scarring outcomes of pediatric burns patients treated surgically vs. those treated conservatively. Front Surg. 2022 Sep 9;9:727983. doi: 10.3389/fsurg.2022.727983. PMID: 36157426; PMCID: PMC9500338.
McCallion O, Bilici M, Hester J, Issa F. Regulatory T-cell therapy approaches. Clin Exp Immunol. 2023 Mar 16;211(2):96-107. doi: 10.1093/cei/uxac078. PMID: 35960852; PMCID: PMC10019137.
Bottomley MJ, Harden PN, Wood KJ, Hester J, Issa F. Dampened Inflammatory Signalling and Myeloid-Derived Suppressor-Like Cell Accumulation Reduces Circulating Monocytic HLA-DR Density and May Associate With Malignancy Risk in Long-Term Renal Transplant Recipients. Front Immunol. 2022 Jul 1;13:901273. doi: 10.3389/fimmu.2022.901273. PMID: 35844527; PMCID: PMC9283730.
Mistry R, Veres M, Issa F. A Systematic Review Comparing Animal and Human Scarring Models. Front Surg. 2022 Apr 22;9:711094. doi: 10.3389/fsurg.2022.711094. PMID: 35529910; PMCID: PMC9073696.
Brook MO, Hester J, Petchey W, Rombach I, Dutton S, Bottomley MJ, Black J, Abdul-Wahab S, Bushell A, Lombardi G, Wood K, Friend P, Harden P, Issa F. Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients. BMJ Open. 2022 Apr 15;12(4):e061864. doi: 10.1136/bmjopen-2022-061864. PMID: 35428650; PMCID: PMC9014059.
Kaiser D, Otto NM, McCallion O, Hoffmann H, Zarrinrad G, Stein M, Beier C, Matz I, Herschel M, Hester J, Moll G, Issa F, Reinke P, Roemhild A. Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo. Front Cell Dev Biol. 2021 Dec 3;9:750286. doi: 10.3389/fcell.2021.750286. PMID: 34926446; PMCID: PMC8677839.
Bottomley MJ, Brook MO, Shankar S, Hester J, Issa F. Towards regulatory cellular therapies in solid organ transplantation. Trends Immunol. 2022 Jan;43(1):8-21. doi: 10.1016/j.it.2021.11.001. Epub 2021 Nov 26. PMID: 34844848.
Choo AMH, Ong YS, Issa F. Scar Assessment Tools: How Do They Compare? Front Surg. 2021 Jun 23;8:643098. doi: 10.3389/fsurg.2021.643098. PMID: 34250003; PMCID: PMC8260845.
Adigbli G, Hua P, Uchiyama M, Roberts I, Hester J, Watt SM, Issa F. Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo. Front Immunol. 2021 Mar 25;12:642198. doi: 10.3389/fimmu.2021.642198. PMID: 33868276; PMCID: PMC8044770.
Stark HL, Wang HC, Kuburic J, Alzhrani A, Hester J, Issa F. Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When? Front Immunol. 2021 Mar 25;12:664244. doi: 10.3389/fimmu.2021.664244. PMID: 33841448; PMCID: PMC8027493.
Hennessy C, Lewik G, Cross A, Hester J, Issa F. Recent advances in our understanding of the allograft response. Fac Rev. 2021 Feb 25;10:21. doi: 10.12703/r/10-21. PMID: 33718938; PMCID: PMC7946390.
Honeyman C, Stark H, Wang HC, Hester J, Issa F, Giele H. Biomarker and surrogate development in vascularised composite allograft transplantation: Current progress and future challenges. J Plast Reconstr Aesthet Surg. 2021 Apr;74(4):711-717. doi: 10.1016/j.bjps.2020.11.022. Epub 2020 Dec 2. PMID: 33436335.
Hartmeier PR, Pham NB, Velankar KY, Issa F, Giannoukakis N, Meng WS. Hydrogel Dressings for Chronic Wound Healing in Diabetes: Beyond Hydration. J Pharm Drug Deliv Res. 2021;10(1):1000197. Epub 2020 Dec 21. PMID: 36110983; PMCID: PMC9473423.
Alzhrani A, Bottomley M, Wood K, Hester J, Issa F. Identification, selection, and expansion of non-gene modified alloantigen-reactive Tregs for clinical therapeutic use. Cell Immunol. 2020 Nov;357:104214. doi: 10.1016/j.cellimm.2020.104214. Epub 2020 Sep 9. PMID: 32977154; PMCID: PMC8482792.
Arroyo Hornero R, Georgiadis C, Hua P, Trzupek D, He LZ, Qasim W, Todd JA, Ferreira RC, Wood KJ, Issa F, Hester J. CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells. Commun Biol. 2020 Jul 14;3(1):375. doi: 10.1038/s42003-020-1097-8. PMID: 32665635; PMCID: PMC7360768.
Min Hui Choo A, Siang Ong Y, Issa F. Scar Assessment Tools: How Do They Compare? Frontiers in Surgery. June 2021. 23;8:643098. doi: 10.3389/fsurg.2021.643098.
Geoghegan L, Al-Khalil M, Scarborough A, Murray A, Issa F. Pre-transplant management and sensitisation in vascularised composite allotransplantation: A systematic review. J Plast Reconstr Aesthet Surg. 2020 Sep;73(9):1593-1603. doi: 10.1016/j.bjps.2020.05.010.
Wright EH, Furniss D, Harris A, Pleat JM, Tyler MPH. A human model of burn injury that quantifies the benefit of cooling as a first aid measure. British Journal of Surgery. In press, 2019. doi.org/10.1002/bjs.11263
M Song, A Armstrong, A Murray. Acid Attacks: Broadening the multidisciplinary team to improve outcomes. Burns, Jun 20, 2019. DIO: 10.1016/j.burns.2019.03.018
Major M, Freund MK, Burch KS, Mancuso N, Ng M, Furniss D, Pasaniuc B, Ophoff RA. Integrative analysis of Dupuytren’s disease identifies novel risk locus and reveals a shared genetic etiology with BMI. Genet Epidemiol. 2019 May 13. doi: 10.1002/gepi.22209.
Wright S, Issa F. Hypoimmunogenic genetically-modified induced pluripotent stem cells for tissue regeneration. Transplantation. 2019 Apr 8. doi: 10.1097/TP.0000000000002754
Issa F, Milward K, Goto R, Betts G, Wood KJ, Hester J. Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo. Front Immunol. 2019 Apr 24;10:889. doi: 10.3389/fimmu.2019.00889. eCollection 2019.
Phillips GSA, Gore S, Ramsden A, Furniss D. Lymphaticovenular anastomosis in the treatment of secondary lymphoedema of the legs after cancer treatment. J Plast Reconstr Aesthet Surg. 2019 Mar 23. pii: S1748-6815(19)30122-6. doi: 10.1016/j.bjps.2019.03.013.
Jones ME, Davies MAM, Shah K, Kemp S, Peirce N, Leyland KM, Stokes KA, Judge AD, Newton JL, Furniss D, Arden NK. The prevalence of hand and wrist osteoarthritis in elite former cricket and rugby union players. J Sci Med Sport. 2019 Mar 16. pii: S1440-2440(18)30971-X. doi: 10.1016/j.jsams.2019.03.004.
Wiberg A, Ng M, Schmid AB, Smillie RW, Baskozos G, Holmes MV, Künnapuu K, Mägi R, Bennett DL, Furniss D. A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nat Commun. 2019 Mar 4;10(1):1030. doi: 10.1038/s41467-019-08993-6.
Craig RS, Lane JCE, Carr AJ, Furniss D, Collins GS, Rees JL. Serious adverse events and lifetime risk of reoperation after elective shoulder replacement: population based cohort study using hospital episode statistics for England. BMJ. 2019 Feb 20;364:l298. doi: 10.1136/bmj.l298.
Markkula SP, Leung N, Allen VB, Furniss D. Surgical interventions for the prevention or treatment of lymphoedema after breast cancer treatment. Cochrane Database Syst Rev. 2019 Feb 19;2:CD011433. doi: 10.1002/14651858.CD011433.pub2.
Manley OWG, Wormald JCR, Furniss D. The changing shape of hand trauma: an analysis of Hospital Episode Statistics in England. J Hand Surg Eur Vol. 2019 Jun;44(5):532-536. doi: 10.1177/1753193419828986. Epub 2019 Feb 14.
Riesmeijer SA, Manley OWG, Ng M, Nolte IM, Broekstra DC, Werker PMN, Furniss D. A Weighted Genetic Risk Score Predicts Surgical Recurrence Independent of High-Risk Clinical Features in Dupuytren’s Disease. Plast Reconstr Surg. 2019 Feb;143(2):512-518. doi: 10.1097/PRS.0000000000005208
McCallion O, Hester J, Issa F. Deciphering the Contribution of γδ T Cells to Outcomes in Transplantation. Transplantation. 2018 Dec;102(12):1983-1993. doi: 10.1097/TP.0000000000002335.
Ali SR, Pleat J. The Gallipot Method-A Point of Technique for Safe and Easy Staple Removal From Split-Thickness Skin Grafts. Eplasty. 2018 Nov 19;18:e32. eCollection 2018
Shah K, Furniss D, Cogswell L. Letter about a Published Paper: The hand injury caused by cutting avocado in 18 patients. J Hand Surg Eur Vol. 2018 Oct;43(8):895-896. doi: 10.1177/1753193418789305.
Edmondson SJ, Murray A. Is the time right to put down the knife? A letter in response with a call for change in primary research outcomes to tackle the global burden of long-term scarring. Burns. 2018 Nov;44(7):1860-1861. doi: 10.1016/j.burns.2018.05.003. Epub 2018 Aug 1.
Edmondson SJ, Ali Jumabhoy I, Murray A. Time to start putting down the knife: A systematic review of burns excision tools of randomised and non-randomised trials. Burns. 2018 Nov;44(7):1721-1737. doi: 10.1016/j.burns.2018.01.012. Epub 2018 Feb 16. Review.
C Brady, S J Edmondson, A Murray. Ensuring sustainability for UK Burns Services: workforce planning for burns consultants., Annals of Plastic Surgery, Sept 2018.
Kawai K, Uchiyama M, Hester J, Wood K, Issa F. Regulatory T cells for tolerance. Hum Immunol. 2018 May;79(5):294-303. doi: 10.1016/j.humimm.2017.12.013. Epub 2017 Dec 27. Review.
D Markeson, A Arnout, M Tyler, A Murray. An epidemiological study of first aid techniques for paediatric burns in different groups and an analysis of outcomes. ABA, Journal of Burn Care and Research, April 2018.
Liu J, Ren J, Su L, Cheng S, Zhou J, Ye X, Dong Y, Sun S, Qi F, Liu Z, Pleat J, Zhai H, Zhu N. Human adipose tissue-derived stem cells inhibit the activity of keloid fibroblasts and fibrosis in a keloid model by paracrine signaling. Burns. 2018 Mar;44(2):370-385. doi: 10.1016/j.burns.2017.08.017. Epub 2017 Oct 10.
Adigbli G, Issa F. Preserving Treg Function: Beyond mTOR Inhibitors. Transplantation. 2018 Feb;102(2):179-182. doi: 10.1097/TP.0000000000002042.
Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.
Watt SM, Pleat JM. Stem cells, niches and scaffolds: Applications to burns and wound care. Adv Drug Deliv Rev. 2018 Jan 1;123:82-106. doi: 10.1016/j.addr.2017.10.012. Epub 2017 Oct 26. Review.
Chapman LA, Shipley RJ, Whiteley JP, Ellis MJ, Byrne HM, Waters SL. Optimising cell aggregate expansion in a perfused hollow fibre bioreactor via mathematical modelling. PLoS One 2014; 26: 9(8)
Issa F and Wood KJ. The potential role for regulatory T cell therapy in vascularised composite allograft transplantation. Curr Opin Organ Transplant 2014;19(6):558-65.
Wung N, Acott SM, Tosh D, Ellis MJ. Hollow fibre membrane bioreactors for tissue engineering applications. Biotechnol Lett 2014; 36(12): 2357-66
Fitzgerald O’Connor E, Frew Q, Din A, Pleat J, Ashraff S, Ghazi-Nouri S, El-Muttardi N, Philp B, Dziewulski P. Periorbital burns – A 6 year review of management and outcome. Burns 2014; S0305-4179(14)00296-4. doi: 10.1016/j.burns.2014.08.022.
Griffiths C, Armstrong-James L, White P, Rumsey N, Pleat J, Harcourt D. A systematic review of patient reported outcome measures (PROMs) used in child and adolescent burn research. Burns 2014; S0305- 4179(14)00246-0
Landwehr-Kenzel S, Issa F, Luu SH, Schmück M, Lei H, Zobel A, Thiel A, Babel N, Wood KJ, Volk HD, Reinke P. Novel GMP-compliant protocol employing an allogeneic B cell bank to induce clonal expansion of even low-abundance alloantigen-specific natural regulatory T cells. Am J Transplant 2014; 14(3):594-606
Newey SE, Tsaknakis G, Khoo CP, Athanassopoulos T, Camicia R, Zhang Y, Grabowska R, HarrisAL, Roubelakis MG, Watt SM. The hematopoietic chemokine CXCL12 promotes integration of human endothelial colony forming cell-derived cells into immature vessel networks. Stem Cells Dev 2014;23(22):2730-43
Paget JT, Burge TS. Keeping New Delhi metallo-β-lactamase-1 at the door. J Burn Care Res 2014; 35(2):e125-7
Allin B, Ceresa C, Issa F, Casey G, Espinosa O, Reddy S, Sinha S, Giele H, Friend P, Vaidya A. A single centre experience of abdominal wall graft rejection after combined intestinal and abdominal wall transplantation. Am J Transplant 2013; 13(8):2211-5
Bendon CL, Furniss D, McNab I. Response to “Scaphoid waist nonunion with humpback deformity treated without structural bone graft”. J Hand Surg Am 2013; 38(9):1866-7
Chandrasekharan D, Issa F, Wood KJ. Achieving operational tolerance in transplantation: how can lessons from the clinic inform research directions? Transplant Int 2013; 26(6):576-89
Capstick R, Bragg T, Giele H, Furniss D. Sibling recurrence risk in Dupuytren’s disease. J Hand Surg 2013;38(4):424-9
Evgeniou E, Markeson D, Iyer S, Armstrong A. The management of animal bites in the United kingdom. Eplasty 2013;13:e27
Finnerty CC, Mabvuure NT, Ali A, Kozar RA, Herndon DN. The surgically induced stress response. J Parenter Enteral Nutr 2013; 37(5): 21-9.
Goto R, Issa F, Heidt S, Taggart D, Wood KJ. Ischaemia-reperfusion injury accelerates human antibody mediated transplant vasculopathy. Transplantation 2013; 96(2):139-45
Isherwood J, Furniss D, Ramsden A. The effectiveness of an educational intervention in improving accuracy of drain output measurements. Int J Surg 2013;11(8):688
Issa F, Robb R, Wood KJ. The where and when of T cell regulation in transplantation. Trends Immunol 2013; 34(3): 107-113
Markeson D, Pleat JM, Sharpe JR, Harris AL, Seifalian AM, Watt SM. Scarring, stem cells, scaffolds and skin repair. J Tissue Eng Regen Med 2013; doi: 10.1002/term.1841
Markeson DB, Evgeniou E, Choa R, Iyer S. The simple transverse intraosseous phalangeal suture for zone 1 flexor digitorum profundus injuries: case series and review of the literature. Plast Reconstr Surg 2013;131(5):788e-93e
Milward J, Issa F, Hester J, Lombardi G, Madrigal A, Wood KJ. Multiple unit pooled umbilical cord blood Treg are a viable source of therapeutic regulatory T cells. Transplantation 2013; 95(1): 85-93.
Murphy G, Markeson D, Choa R, Armstrong A. Raised serum lactate: a marker of necrotizing fasciitis? J Plast Reconstr Aesthet Surg 2013; 66(12):1712-6
Roubelakis MG, Tsaknakis G, Pappa KI, Anagnou NP, Watt SM (2013). Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization. PLoS One 2013;8(1):e54747.
Watt SM, Gullo F, van der Garde M, Markeson D, Camicia R, Khoo CP, Zwaginga JJ. The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential. Br Med Bull 2013;108:25-53
Books or Book Chapters Published
Issa, F. Transplant Tolerance: Lessons from Experimental Models. NDT Educational
Mabvuure NT, Munson C, Pleat J. The pathophysiological response to burns. In: The Oxford Handbook of Burns. OUP, Oxford 2014.
Watt SM, Leeson P, Cai S, Markeson D, Khoo CP, Newton L, Zhang Y, Sourri S, Channon KM. Cord and cord blood endothelial cells- Chapter 5. In: Cord Blood Stem Cells and Regenerative Medicine. C Stavropoulos et al.eds. Elsevier Press, Amsterdam, The Netherlands 2014.
Oral Presentions
Patricia Perez-Esteban, “Scaling-up of Keratinocyte Expansion for the Treatment of Large Burn Wounds”, lifETIME CDT meeting, Birmingham, 2019
Rebecca Arroyo Hornero, “CD70 expression renders human regulatory T cells dysfunctional”, Oxford Immunology Symposium, 2018
Riyam Mistry, “A human trial of an anti-scarring therapy”. Vocational Training Charitable Trust, London, 2018
Alexandra Murray, “Acid Attacks in the UK, Oral presentation”, British Burns Association Congress, Swansea 2018
Alexandra Murray, “Paediatric Scalds – management and outcomes”, Oral presentation, British Burns Association Congress, Swansea 2018
Guy Stanley, “An international study of public perceptions of keloids”, Australian and New Zealand Burns Association, 2018
Poster Presentations
BEST Protocol, British Burns Association Congress, Leeds 2019
Paediatric Scald scar follow up, British Burns Association Congress, Leeds 2019. Best in category.
Higher Degrees
Hugh Wright, University of Oxford, Doctorate of Philosophy, 2019.
Rebeca Arroyo Hornero, University of Oxford, DPhil Surgical Sciences, 2019
Riyam Mistry transfer viva; Master of Surgery, 2019